Description

Methyl 3-Fluoro-5-Iodobenzoate is a high-purity, multi-functional organic building block essential for advanced chemical synthesis. Its unique structure, featuring both fluorine and iodine substituents, makes it a critical intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for drug discovery and the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and pesticides, where the fluorine and iodine atoms can enhance biological activity and environmental stability.
• Material Science Precursor: Serves as a monomer or precursor for synthesizing specialty polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: The iodine moiety makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to create complex biaryl structures.
• Fluorine Chemistry Studies: Employed in medicinal chemistry to study the effects of fluorine substitution on a benzoate scaffold, influencing metabolism, bioavailability, and binding affinity.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds and reference standards.

Basic Information

Product Name	Methyl 3-Fluoro-5-Iodobenzoate
CAS No.	1261478-09-4
Molecular Formula	C8H6FIO2
Molecular Weight	280.04 g/mol
Synonyms	3-Fluoro-5-iodobenzoic acid methyl ester; Methyl 3-fluoro-5-iodobenzoate; Benzoic acid, 3-fluoro-5-iodo-, methyl ester; Methyl 3-fluoro-5-iodobenzenecarboxylate; 5-Iodo-3-fluorobenzoic acid methyl ester; 3-Fluoro-5-iodo-methylbenzoate
EINECS	Contact for details

Quality Control

Our Methyl 3-Fluoro-5-Iodobenzoate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with customer specifications. Our quality commitment supports applications in GMP and ISO-regulated environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong oxidizing agents and bases. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Heavy Metals	< 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.