Description

1-[3-Fluoro-5-(Trifluoromethyl)Phenyl]Cyclopropane-1-Carboxylic Acid is a high-value, multifunctional organic building block characterized by its unique cyclopropane carboxylic acid core flanked by fluorine and trifluoromethyl substituents. This compound matters for its role as a critical intermediate in the synthesis of advanced pharmaceutical candidates and agrochemicals, where its structure imparts desirable metabolic stability and lipophilicity. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to incorporate fluorinated motifs into novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas targeting the central nervous system, oncology, and inflammation.
• Agrochemical Synthesis: Serves as a precursor for advanced herbicides, fungicides, and insecticides, leveraging the fluorine atoms to enhance biological activity and environmental persistence.
• Ligand & Catalyst Development: Used in organometallic chemistry and catalysis research to create novel ligands for transition metal complexes.
• Material Science Research: Employed in the synthesis of fluorinated polymers and advanced organic materials with specific electronic or surface properties.
• Chemical Biology Probes: Useful for constructing molecular probes and tags for studying biological processes due to the distinctive properties of the trifluoromethyl group.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	1-[3-Fluoro-5-(Trifluoromethyl)Phenyl]Cyclopropane-1-Carboxylic Acid
CAS No.	1260780-99-1
Molecular Formula	C11H8F4O2
Molecular Weight	248.17 g/mol
Synonyms	[3-Fluoro-5-(trifluoromethyl)phenyl]cyclopropanecarboxylic acid; 1-(3-Fluoro-5-(trifluoromethyl)phenyl)cyclopropanecarboxylic acid; Cyclopropanecarboxylic acid, 1-[3-fluoro-5-(trifluoromethyl)phenyl]-; 1-(3-Fluoro-5-trifluoromethylphenyl)cyclopropane-1-carboxylic acid; 3-Fluoro-5-(trifluoromethyl)benzenecarboxylic acid cyclopropane derivative
EINECS	Contact for details

Quality Control

Our production of 1-[3-Fluoro-5-(Trifluoromethyl)Phenyl]Cyclopropane-1-Carboxylic Acid adheres to stringent in-process and final release controls. Every batch is characterized and tested to ensure identity, purity, and consistency, meeting the exacting standards required for pharmaceutical and agrochemical R&D. A comprehensive Certificate of Analysis (COA) detailing purity (typically by HPLC), assay, and impurity profile is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). The compound may be hygroscopic; keep the container tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.