Description

trans-2-(3-(Difluoromethoxy)Phenyl)Cyclopropane-1-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate featuring a unique cyclopropane carboxylic acid core substituted with a difluoromethoxy phenyl group. This compound is valued for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring specific stereochemistry and fluorinated motifs. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of next-generation small molecule drugs.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new drug candidates.
• Agrochemical Synthesis: Used in the creation of advanced crop protection agents and herbicides.
• Ligand and Catalyst Development: Serves as a precursor for specialized ligands in asymmetric catalysis.
• Material Science Research: Investigated as a monomer or additive for specialty polymers with unique properties.
• Chemical Biology Probes: Employed in the design of molecular probes for studying enzyme mechanisms and biological pathways.

Basic Information

Product Name	trans-2-(3-(Difluoromethoxy)Phenyl)Cyclopropane-1-Carboxylic Acid
CAS No.	1257121-09-7
Molecular Formula	C11H10F2O3
Molecular Weight	228.19 g/mol
Synonyms	(1R,2S)-2-[3-(Difluoromethoxy)phenyl]cyclopropane-1-carboxylic acid; (1S,2R)-2-[3-(Difluoromethoxy)phenyl]cyclopropane-1-carboxylic acid; trans-2-(3-(Difluoromethoxyphenyl))cyclopropanecarboxylic Acid; 2-(3-(Difluoromethoxy)phenyl)cyclopropanecarboxylic acid; DFM-CPA; 1257121-09-7
EINECS	Contact for details

Quality Control

Our trans-2-(3-(Difluoromethoxy)Phenyl)Cyclopropane-1-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the stringent requirements for pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting identity, purity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible materials. For long-term storage, consider inert atmosphere conditions to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (trans isomer)
Related Substances (HPLC)	Any single impurity ≤ 0.5% Total impurities ≤ 1.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.