Description

5-(Difluoromethyl)Nicotinic Acid is a high-value fluorinated pyridine derivative, serving as a critical building block in modern synthetic chemistry. Its unique difluoromethyl-substituted nicotinic acid structure makes it an essential intermediate for developing novel active pharmaceutical ingredients (APIs) and agrochemicals. This compound is primarily sought after by research institutions and manufacturers in the pharmaceutical, agrochemical, and advanced material sectors for creating compounds with enhanced metabolic stability and bioavailability.

Application

• Pharmaceutical Intermediate: Key synthon for the development of novel drug candidates, particularly in kinase inhibitor and antiviral research.
• Agrochemical Synthesis: Used in the production of advanced herbicides and fungicides, where the difluoromethyl group improves efficacy and environmental profile.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in transition metal catalysis and organocatalysis.
• Material Science Research: Employed in the synthesis of fluorinated organic semiconductors and liquid crystal materials.
• Chemical Biology Probes: Utilized to create fluorinated analogs of natural products for mechanism-of-action studies.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis projects requiring the introduction of a difluoromethylated pyridine moiety.

Basic Information

Product Name	5-(Difluoromethyl)Nicotinic Acid
CAS No.	1256817-25-0
Molecular Formula	C7H5F2NO2
Molecular Weight	173.12 g/mol
Synonyms	5-(Difluoromethyl)pyridine-3-carboxylic acid; Nicotinic acid, 5-(difluoromethyl)-; 3-Pyridinecarboxylic acid, 5-(difluoromethyl)-; 5-Difluoromethylnicotinic acid; 5-(Difluoromethyl)-3-pyridinecarboxylic acid; Difluoromethylnicotinic acid
EINECS	Contact for details

Quality Control

Our 5-(Difluoromethyl)Nicotinic Acid is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. We employ advanced analytical techniques, including HPLC, GC, NMR, and MS, for comprehensive identity confirmation and impurity profiling. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting purity, assay, and relevant physicochemical parameters to meet the stringent requirements of our global clientele in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong acids, bases, and oxidizing agents. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.