Description

2,2-Difluoro-2-(2-Methoxyphenyl)Acetic Acid is a high-value fluorinated aromatic building block characterized by its difluoroacetic acid moiety attached to a methoxyphenyl ring. This compound matters as a critical synthetic intermediate, enabling the introduction of a difluoroacetate group into complex molecules, which is a key strategy in modern medicinal chemistry for modulating pharmacokinetic properties. Pharmaceutical R&D and fine chemical synthesis professionals need it for the development of novel active pharmaceutical ingredients (APIs), agrochemicals, and advanced materials.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing drug candidates, particularly in the development of protease inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and pesticides where the difluoro group enhances biological activity and stability.
• Material Science Research: Serves as a precursor for specialty polymers and liquid crystals that require fluorinated aromatic components.
• Organic Synthesis Reagent: Employed in academic and industrial laboratories for constructing complex organic molecules via reactions like esterification, amidation, and cross-coupling.
• Fluorine Chemistry Studies: A valuable compound for investigating the effects of gem-difluoro substitution adjacent to a carbonyl group on reactivity and molecular conformation.

Basic Information

Product Name	2,2-Difluoro-2-(2-Methoxyphenyl)Acetic Acid
CAS No.	1250773-62-6
Molecular Formula	C9H8F2O3
Molecular Weight	202.16 g/mol
Synonyms	2-(2-Methoxyphenyl)-2,2-difluoroacetic Acid; α,α-Difluoro-2-methoxyphenylacetic Acid; 2-Methoxyphenyl(difluoro)acetic Acid; (2-Methoxyphenyl)difluoroacetic Acid; Difluoro(2-methoxyphenyl)acetic Acid; 2,2-Difluoro-2-(o-methoxyphenyl)acetic Acid; o-Methoxyphenyl(difluoro)acetic Acid
EINECS	Contact for details

Quality Control

Our 2,2-Difluoro-2-(2-Methoxyphenyl)Acetic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and synthesis. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.