Description

3-Bromo-2-(Difluoromethoxy)Benzoic Acid is a high-value, multi-functional aromatic building block characterized by its unique combination of bromine and difluoromethoxy substituents. This compound is essential for the synthesis of complex molecules, offering chemists a versatile handle for cross-coupling reactions and the introduction of fluorine motifs to modulate biological activity and physicochemical properties. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for creating novel active ingredients and advanced intermediates.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, inflammatory diseases, and oncology.
• Agrochemical Synthesis: Used in the creation of advanced herbicides, fungicides, and insecticides, where the difluoromethoxy group can enhance metabolic stability and lipophilicity.
• Material Science Precursor: Serves as a building block for specialty polymers and liquid crystals, where its aromatic core and halogenated groups influence material properties.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for Suzuki, Stille, and Buchwald-Hartwig amination reactions to construct complex biaryl systems.
• Fluorine Chemistry Research: An important compound for studying the effects of fluorine and fluorinated alkoxy groups on molecular conformation and bioactivity in medicinal chemistry programs.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of tailored intermediates under cGMP or research-grade conditions.

Basic Information

Product Name	3-Bromo-2-(Difluoromethoxy)Benzoic Acid
CAS No.	1249235-55-9
Molecular Formula	C8H5BrF2O3
Molecular Weight	267.03 g/mol
Synonyms	3-Bromo-2-(difluoromethoxy)benzoic acid; Benzoic acid, 3-bromo-2-(difluoromethoxy)-; 2-(Difluoromethoxy)-3-bromobenzoic acid; 3-Bromo-2-difluoromethoxybenzoic acid; 1249235-55-9; 3-Br-2-(OCHF2)Benzoic Acid
EINECS	Contact for details

Quality Control

Our 3-Bromo-2-(Difluoromethoxy)Benzoic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure it meets the high standards required for research and development applications. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and physical characteristics is provided with each shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong bases and fluorides. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.