Description

(S)-Bendroflumethiazide is the single enantiomer of the thiazide diuretic bendroflumethiazide, identified by CAS NO 1245935-40-3. This high-purity chiral building block is critical for pharmaceutical research and development, particularly in the study of stereospecific drug activity and metabolism. It is primarily required by pharmaceutical R&D laboratories, analytical reference standard providers, and manufacturers of advanced active pharmaceutical ingredients (APIs) for hypertension and edema treatment.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for analytical method development, validation, and quality control in pharmacopeial testing.
• Chiral Intermediate Synthesis: Serves as a key starting material or intermediate in the enantioselective synthesis of novel diuretic compounds and stereochemically pure APIs.
• Metabolic and Pharmacokinetic Studies: Employed in preclinical and clinical research to investigate the distinct biological activity, absorption, and excretion profile of the (S)-enantiomer.
• Impurity Profiling: Utilized as a marker to identify and quantify the (S)-enantiomer as a potential impurity in racemic bendroflumethiazide drug substances and finished dosage forms.
• Academic and Institutional Research: Applied in university and government labs for fundamental research on renal physiology, ion transport mechanisms, and structure-activity relationships (SAR).

Basic Information

Product Name	(S)-Bendroflumethiazide
CAS No.	1245935-40-3
Molecular Formula	C15H14F3N3O4S2
Molecular Weight	421.41 g/mol
Synonyms	(S)-3-Benzyl-6-(trifluoromethyl)-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide; (S)-Bendroflumethiazide; (S)-Bendrofluazide; (S)-BFTZ; (S)-Benzylhydroflumethiazide; (S)-Naturetin; (S)-Aprinox; (S)-Bendroflumetiazida
EINECS	Contact for details

Quality Control

Our (S)-Bendroflumethiazide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets stringent specifications for research and pharmaceutical applications. Certificates of Analysis (COA) with detailed chromatographic data, including enantiomeric excess (ee), are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the material should be handled in a low-humidity environment and the container kept sealed when not in use to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Enantiomeric Excess)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.