Description

4-(Carboxydifluoromethyl)Benzoic Acid is a specialized difluoromethylated benzoic acid derivative, serving as a critical building block in advanced organic synthesis. Its unique structure, featuring both a carboxylic acid and a difluoromethylcarboxylic acid group, makes it a valuable precursor for creating complex molecules with tailored properties. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for applications such as medicinal chemistry and material science.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in the creation of fluorine-containing drug candidates.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the difluoromethyl group can enhance biological activity and metabolic stability.
• Ligand and Catalyst Development: Serves as a precursor for synthesizing specialized ligands and metal-organic frameworks (MOFs) used in catalysis.
• Material Science Research: Employed in the synthesis of functional polymers and advanced organic materials with specific electronic or surface properties.
• Fluorine Chemistry Studies: Acts as a model compound in academic and industrial research exploring new fluorination methodologies and reaction pathways.
• Custom Synthesis Building Block: Provides a versatile handle for contract research organizations (CROs) and fine chemical manufacturers engaged in custom synthesis projects.

Basic Information

Product Name	4-(Carboxydifluoromethyl)Benzoic Acid
CAS No.	1240313-90-9
Molecular Formula	C9H6F2O4
Molecular Weight	216.14 g/mol
Synonyms	4-(Difluorocarboxymethyl)benzoic acid; Benzoic acid, 4-[(difluorocarbonyl)methyl]-; 4-(Difluoromethylcarboxyl)benzoic acid; 4-[(Difluorocarbonyl)methyl]benzoic acid; 4-(Carboxy(difluoro)methyl)benzoic acid; α,α-Difluoro-4-carboxybenzeneacetic acid; 4-(1,1-Difluoro-2-carboxyethyl)benzoic acid (tautomeric form)
EINECS	Contact for details

Quality Control

Our 4-(Carboxydifluoromethyl)Benzoic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, ensuring full traceability and compliance with your internal quality protocols.

Storage

Preserve in a tightly closed container, protected from light. Due to its hygroscopic (moisture-sensitive) nature, the container should be kept in a cool, dry place with minimal exposure to humidity. For long-term storage, consider using a desiccant. Recommended storage temperature is 2-8°C to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.