Description

3-Chloro-3'-(Trifluoromethyl)-[1,1'-Biphenyl]-4-Carboxylic Acid is a high-purity biphenyl derivative carboxylic acid, distinguished by its chloro and trifluoromethyl substituents. This compound serves as a critical building block in advanced organic synthesis, offering unique steric and electronic properties for constructing complex molecular architectures. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) and metabolic diseases.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and fungicides, where the biphenyl core and fluorine atoms contribute to biological activity and environmental stability.
• Ligand & Catalyst Development: Serves as a precursor for chiral ligands or metal-organic frameworks (MOFs) in asymmetric catalysis and material science applications.
• Liquid Crystal & OLED Materials: Acts as a functionalized core unit in the development of specialty electronic materials for displays and lighting.
• Polymer Modification: Employed to introduce aromatic and fluorinated groups into polymer backbones to enhance thermal stability, chemical resistance, and optical properties.
• Custom Synthesis & Contract Research: Supplied to CROs and CDMOs for bespoke synthesis projects requiring specific, high-value biphenyl carboxylic acids.

Basic Information

Product Name	3-Chloro-3'-(Trifluoromethyl)-[1,1'-Biphenyl]-4-Carboxylic Acid
CAS No.	1238694-75-1
Molecular Formula	C14H8ClF3O2
Molecular Weight	300.66 g/mol
Synonyms	3-Chloro-3'-(trifluoromethyl)biphenyl-4-carboxylic acid; [1,1'-Biphenyl]-4-carboxylic acid, 3-chloro-3'-(trifluoromethyl)-; 3'-Chloro-3-(trifluoromethyl)[1,1'-biphenyl]-4-carboxylic acid; 4-Biphenylcarboxylic acid, 3-chloro-3'-trifluoromethyl-; 3-Chloro-3'-trifluoromethylbiphenyl-4-carboxylic acid; Biphenyl-4-carboxylic acid derivative
EINECS	Contact for details

Quality Control

Our 3-Chloro-3'-(Trifluoromethyl)-[1,1'-Biphenyl]-4-Carboxylic Acid is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, documenting all critical quality attributes. Our quality commitment aligns with cGMP and ISO 9001 principles to support our customers' regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. The container must be kept tightly sealed to protect the contents from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.