Description

2-Fluoro-6-(Pyrrolidin-1-Yl)Isonicotinic Acid is a high-value, heterocyclic building block featuring a strategically functionalized pyridine core. This compound matters as a critical intermediate in modern pharmaceutical research and development, enabling the synthesis of novel drug candidates. It is primarily needed by medicinal chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing complex molecules with targeted biological activity.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and central nervous system (CNS) drug discovery programs.
• Medicinal Chemistry Research: Used in high-throughput screening and combinatorial chemistry to create diverse compound libraries for biological evaluation.
• Agrochemical Development: Serves as a precursor in the design and synthesis of new herbicides, fungicides, and plant growth regulators.
• Chemical Biology Probe Synthesis: Employed to create molecular tools for studying enzyme function and cellular signaling pathways.
• Material Science Research: Potential monomer or precursor for advanced polymers and liquid crystals due to its rigid, functionalized structure.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting outsourced drug discovery and development projects.

Basic Information

Product Name	2-Fluoro-6-(Pyrrolidin-1-Yl)Isonicotinic Acid
CAS No.	1228665-96-0
Molecular Formula	C10H11FN2O2
Molecular Weight	210.21 g/mol
Synonyms	2-Fluoro-6-(1-pyrrolidinyl)isonicotinic acid; 6-(Pyrrolidin-1-yl)-2-fluoropyridine-4-carboxylic acid; 2-Fluoro-6-(pyrrolidin-1-yl)isonicotinic acid; 2-Fluoro-6-pyrrolidin-1-ylpyridine-4-carboxylic acid; 4-Pyridinecarboxylic acid, 2-fluoro-6-(1-pyrrolidinyl)-; 2-Fluoro-6-pyrrolidin-1-yl-isonicotinic acid; 1228665-96-0; AKOS026710915
EINECS	Contact for details

Quality Control

Our 2-Fluoro-6-(Pyrrolidin-1-Yl)Isonicotinic Acid is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with agreed specifications. We support development and commercial projects with material produced under current Good Manufacturing Practice (cGMP) guidelines as required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere or in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.