Description

Ethyl 4-Bromo-2-Chloro-5-Fluorobenzoate is a high-purity, multi-halogenated benzoate ester serving as a critical building block in advanced organic synthesis. Its value lies in providing a versatile and reactive aromatic scaffold for constructing complex molecules, particularly in the pharmaceutical and agrochemical sectors. This compound is essential for researchers and manufacturers developing active pharmaceutical ingredients (APIs), crop protection agents, and specialty materials who require reliable access to high-quality, structurally precise intermediates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders, anti-infectives, and oncology therapeutics.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the halogenated aromatic core contributes to biological activity and stability.
• Liquid Crystal & OLED Material Research: Serves as a starting material for synthesizing fluorinated and halogenated aromatic compounds used in electronic display technologies.
• Cross-Coupling Reactions: The bromo and chloro substituents make it an excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to form biaryl structures.
• Functional Group Transformation: The ester group can be hydrolyzed to the corresponding acid, reduced to the alcohol, or used in further condensation reactions, offering multiple synthetic pathways.
• Chemical Biology & Proteomics: Utilized in creating molecular probes and tags for studying biological processes due to its reactive halogen handles.

Basic Information

Product Name	Ethyl 4-Bromo-2-Chloro-5-Fluorobenzoate
CAS No.	1228376-44-0
Molecular Formula	C9H7BrClFO2
Molecular Weight	281.51 g/mol
Synonyms	4-Bromo-2-chloro-5-fluorobenzoic Acid Ethyl Ester; Benzoic acid, 4-bromo-2-chloro-5-fluoro-, ethyl ester; Ethyl 4-bromo-2-chloro-5-fluorobenzoate; Ethyl 4-Bromo-2-Chloro-5-Fluorobenzoate; 1228376-44-0; 4-Bromo-2-chloro-5-fluorobenzoic acid ethyl ester
EINECS	Contact for details

Quality Control

Our Ethyl 4-Bromo-2-Chloro-5-Fluorobenzoate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment supports compliance with cGMP, ISO, and other relevant regulatory frameworks for pharmaceutical and industrial applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from strong bases and incompatible materials. For long-term storage, consider an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.