Description

(3R,11Br)-Tetrabenazine (1S)-(+)-10-Camphorsulfonate is a high-purity, non-racemic salt form of the active pharmaceutical ingredient Tetrabenazine, distinguished by its specific stereochemistry. This compound is critical for pharmaceutical research and development, particularly in the study and synthesis of enantiomerically pure therapeutics targeting central nervous system disorders. It is primarily required by advanced pharmaceutical manufacturers and research institutions engaged in the development of novel treatments for movement disorders, where precise stereochemical control is paramount for efficacy and safety profiling.

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of enantiomerically pure Tetrabenazine and its analogs for clinical development.
• Reference Standard: Serves as a high-purity certified reference material (CRM) for analytical method development, validation, and quality control in API manufacturing.
• Neurological Research: Used in preclinical and pharmacological studies to investigate vesicular monoamine transporter 2 (VMAT2) inhibition with defined stereochemistry.
• Process Chemistry: Employed in route scouting and optimization for the commercial-scale production of stereospecific active pharmaceutical ingredients (APIs).
• Regulatory Submissions: Provides the necessary characterized material for inclusion in drug master files (DMFs) and investigational new drug (IND) applications.

Basic Information

Product Name	(3R,11Br)-Tetrabenazine (1S)-(+)-10-Camphorsulfonate
CAS No.	1223399-57-2
Molecular Formula	C33H42BrNO6S
Molecular Weight	660.66 g/mol
Synonyms	(+)-Tetrabenazine (1S)-10-Camphorsulfonate Salt; (3R,11bR)-Tetrabenazine (1S)-(+)-10-Camphorsulfonate; TBZ Camphorsulfonate Salt; (3R,11bR)-1,3,4,6,7,11b-Hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzo[a]quinolizin-2-one (1S)-(+)-10-Camphorsulfonate; Deuterabenazine Related Compound; VMAT2 Inhibitor Salt; Xenazine Impurity Salt; Nitoman Intermediate.
EINECS	Contact for details

Quality Control

Our (3R,11Br)-Tetrabenazine (1S)-(+)-10-Camphorsulfonate is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including chiral HPLC, NMR, and mass spectrometry, to confirm identity, purity, and stereochemical integrity. Certificates of Analysis (COA) are provided, detailing all relevant specifications and test results to support your regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.