Description

n-[(3R)-3-(Dimethylamino)-2,3,4,9-Tetrahydro-1H-Carbazol-6-Yl]-4-Fluoro-Benzamide Hydrochloride is a high-purity, non-racemic chiral compound of significant interest in advanced pharmaceutical research and development. This molecule serves as a critical pharmacological reference standard and a key synthetic intermediate for novel therapeutic agents. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions focused on neuroscience and oncology drug discovery.

Application

• Pharmaceutical Reference Standard: Used for analytical method development, validation, and quality control in drug substance and product testing.
• Active Pharmaceutical Ingredient (API) Intermediate: A crucial building block in the multi-step synthesis of complex drug candidates targeting central nervous system disorders.
• Biochemical Research: Employed in in vitro assays to study receptor binding affinity, enzyme inhibition, and other pharmacological mechanisms of action.
• Process Chemistry & Scale-Up: Serves as a starting material or intermediate for process optimization and pilot-scale manufacturing of developmental drugs.
• Metabolite Synthesis: Used in the preparation of potential human metabolites for safety and toxicology studies (ADME).

Basic Information

Product Name	n-[(3R)-3-(Dimethylamino)-2,3,4,9-Tetrahydro-1H-Carbazol-6-Yl]-4-Fluoro-Benzamide Hydrochloride
CAS No.	1217756-94-9
Molecular Formula	C21H23FN3O · HCl
Molecular Weight	397.89 g/mol (Free base: 361.43 g/mol)
Synonyms	4-Fluoro-N-[(3R)-3-(dimethylamino)-1,2,3,4-tetrahydro-9H-carbazol-6-yl]benzamide hydrochloride; (R)-N-(3-(Dimethylamino)-2,3,4,9-tetrahydro-1H-carbazol-6-yl)-4-fluorobenzamide HCl; UNII-7K3Q8WY1J2; 4-Fluoro-N-[(3R)-3-(dimethylamino)-2,3,4,9-tetrahydro-1H-carbazol-6-yl]benzamide monohydrochloride; Carbazole-6-carboxamide derivative; Chiral tetrahydrocarbazole derivative
EINECS	Contact for details

Quality Control

Our n-[(3R)-3-(Dimethylamino)-2,3,4,9-Tetrahydro-1H-Carbazol-6-Yl]-4-Fluoro-Benzamide Hydrochloride is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research applications. All batches are supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, chiral purity, and impurity profiles as determined by advanced analytical techniques including HPLC, NMR, and MS. We adhere to cGMP guidelines for the production of pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere after each use to prevent degradation. For long-term storage, consider storing desiccated at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.