Description

5-Borono-2,3-difluorobenzoic acid is a high-value, multi-functional aromatic building block containing both a boronic acid and a carboxylic acid functional group. This unique bifunctional structure makes it a critical intermediate for the synthesis of complex molecules, particularly in pharmaceutical and advanced material research. It is primarily sought after by R&D chemists and process development scientists in the life sciences and fine chemical sectors for constructing novel active pharmaceutical ingredients (APIs) and functional organic materials.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for the synthesis of biaryl compounds, which are core structures in many drug candidates.
• Proteolysis Targeting Chimera (PROTAC) Development: Used as a versatile linker or warhead component in the design of targeted protein degradation therapeutics.
• Material Science Research: Serves as a monomer or building block for creating novel polymers, metal-organic frameworks (MOFs), and organic electronic materials with tailored properties.
• Agrochemical Synthesis: Employed in the research and development of new herbicides and fungicides that require specific fluorine-substituted aromatic motifs.
• Ligand Synthesis for Catalysis: Utilized to prepare sophisticated bidentate or tridentate ligands for transition metal catalysts used in asymmetric synthesis.
• Diagnostic Reagent Development: Acts as a starting material for synthesizing fluorescent probes or molecular imaging agents.

Basic Information

Product Name	5-Borono-2,3-difluorobenzoic Acid
CAS No.	1217500-81-6
Molecular Formula	C7H5BF2O4
Molecular Weight	201.92 g/mol
Synonyms	2,3-Difluoro-5-boronobenzoic Acid; 5-Carboxy-2,3-difluorophenylboronic Acid; (5-Carboxy-2,3-difluorophenyl)boronic Acid; 2,3-Difluoro-5-carboxyphenylboronic Acid; Benzoic acid, 5-borono-2,3-difluoro-; B-(5-Carboxy-2,3-difluorophenyl)boronic Acid
EINECS	Contact for details

Quality Control

Our 5-Borono-2,3-difluorobenzoic Acid is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and elemental analysis, to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with customer specifications and supporting regulatory filings for research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.