Description

Difluoro[5-(Trifluoromethyl)-Pyridin-2-Yl]Acetic Acid is a high-value fluorinated pyridine derivative that serves as a critical building block in advanced organic synthesis. Its unique structure, featuring both difluoroacetic acid and trifluoromethylpyridine moieties, makes it an essential intermediate for creating novel compounds with enhanced biological activity and physical properties. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of new active ingredients.

Application

• Pharmaceutical Intermediate: Key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in oncology, CNS, and antiviral research.
• Agrochemical Synthesis: Used in the creation of next-generation herbicides, fungicides, and insecticides where the fluorine atoms improve metabolic stability and membrane permeability.
• Material Science Precursor: Serves as a monomer or functionalizing agent for specialty polymers, liquid crystals, and electronic materials requiring fluorinated aromatic systems.
• Chemical Biology Probe Development: Employed in medicinal chemistry for structure-activity relationship (SAR) studies and as a building block for fluorescent tags or molecular probes.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	Difluoro[5-(Trifluoromethyl)-Pyridin-2-Yl]Acetic Acid
CAS No.	1215583-64-4
Molecular Formula	C8H4F5NO2
Molecular Weight	241.12 g/mol
Synonyms	2-(Difluoroacetic acid)-5-(trifluoromethyl)pyridine; [5-(Trifluoromethyl)pyridin-2-yl]difluoroacetic acid; 2,2-Difluoro-2-[5-(trifluoromethyl)pyridin-2-yl]acetic acid; 5-(Trifluoromethyl)pyridine-2-difluoroacetic acid; α,α-Difluoro-5-(trifluoromethyl)picolinic acid; 2-Pyridineacetic acid, α,α-difluoro-5-(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Our Difluoro[5-(Trifluoromethyl)-Pyridin-2-Yl]Acetic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistent composition suitable for sensitive synthetic applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.