Description

tert-Butyl 2-Chloro-5-Fluorobenzoate is a high-purity, synthetically valuable benzoate ester derivative. This compound serves as a crucial advanced pharmaceutical intermediate and versatile building block in organic synthesis. It is primarily utilized by research and development chemists and process scale-up teams in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly those containing fluorinated and chlorinated aromatic systems.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides where the tert-butyl ester group offers strategic synthetic advantages.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in metal-catalyzed cross-coupling reactions and other catalytic processes.
• Material Science Research: Employed in the development of novel organic materials, including liquid crystals and polymers with specific electronic properties.
• Custom Synthesis and Contract Manufacturing: A critical starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.
• Academic and Industrial R&D: Used in research laboratories for method development and exploring new chemical reactions involving halogenated benzoates.

Basic Information

Product Name	tert-Butyl 2-Chloro-5-Fluorobenzoate
CAS No.	1215206-26-0
Molecular Formula	C11H12ClFO2
Molecular Weight	230.66 g/mol
Synonyms	2-Chloro-5-fluorobenzoic acid tert-butyl ester; tert-Butyl 2-chloro-5-fluorobenzoate; Benzoic acid, 2-chloro-5-fluoro-, 1,1-dimethylethyl ester; t-Butyl 2-chloro-5-fluorobenzoate; 2-Chloro-5-fluorobenzoic acid 1,1-dimethylethyl ester; tert-Butyl ester of 2-chloro-5-fluorobenzoic acid
EINECS	Contact for details

Quality Control

Our tert-Butyl 2-Chloro-5-Fluorobenzoate is manufactured under strict quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure high chemical purity and identity confirmation. We provide a detailed Certificate of Analysis (COA) with each shipment, documenting all critical quality attributes. Our production adheres to cGMP (current Good Manufacturing Practice) principles where applicable, ensuring consistency and traceability for demanding industrial and research applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from strong acids and organic solvents. The container must be kept tightly closed to prevent moisture absorption and potential degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥98.0%
Purity (GC)	≥97.0%
Melting Point	Contact for details
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.