Description

4-(Difluoromethoxy)-3-Fluorobenzoic Acid is a high-purity fluorinated benzoic acid derivative, a critical building block in advanced organic synthesis. This compound is valued for its unique difluoromethoxy and fluorine substituents, which are essential for modulating the physicochemical properties of target molecules. It is primarily utilized by research and development chemists and process engineers in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in drug discovery programs targeting metabolic and central nervous system disorders.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, where the fluorine atoms enhance biological activity and environmental stability.
• Liquid Crystal Materials: Serves as a precursor in the production of fluorinated liquid crystals for advanced display technologies.
• Organic Electronic Materials: Employed in the synthesis of specialized monomers and polymers for organic light-emitting diodes (OLEDs) and semiconductors.
• Chemical Research & Development: A versatile reagent for introducing the difluoromethoxy group into complex molecular architectures in academic and industrial R&D settings.
• Fluorine Chemistry Studies: Used as a model compound or starting material in methodological studies exploring new fluorination reactions and mechanisms.

Basic Information

Product Name	4-(Difluoromethoxy)-3-Fluorobenzoic Acid
CAS No.	1214383-15-9
Molecular Formula	C8H5F3O3
Molecular Weight	206.12 g/mol
Synonyms	3-Fluoro-4-(difluoromethoxy)benzoic Acid; Benzoic acid, 3-fluoro-4-(difluoromethoxy)-; 4-(Difluoromethoxy)-3-fluorobenzoic acid; 3-Fluoro-4-difluoromethoxybenzoic Acid; 1214383-15-9; 4-Difluoromethoxy-3-fluorobenzoic Acid
EINECS	Contact for details

Quality Control

Every batch of 4-(Difluoromethoxy)-3-Fluorobenzoic Acid is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.