Description

5-Methoxy-2-(trifluoromethyl)phenylacetic acid is a high-purity, advanced pharmaceutical intermediate characterized by its distinct aromatic acetic acid structure with methoxy and trifluoromethyl substituents. This compound is of significant commercial importance for its role in the synthesis of complex active pharmaceutical ingredients (APIs), where the trifluoromethyl group is a key pharmacophore enhancing metabolic stability and bioavailability. It is primarily sought after by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for developing new therapeutic agents and high-value fine chemicals.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of novel drug candidates, particularly in central nervous system (CNS) and anti-inflammatory therapeutic areas.
• Agrochemical Synthesis: Used in the research and development of advanced pesticides and herbicides, leveraging the biological activity of the trifluoromethyl moiety.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the development of organic electronic materials and liquid crystals due to its specific electronic properties.
• Custom Synthesis and Contract Manufacturing: A key starting material for custom synthesis projects and scale-up processes in fine chemical production.
• Academic and R&D Laboratories: Used in medicinal chemistry programs for structure-activity relationship (SAR) studies and lead optimization.

Basic Information

Product Name	5-Methoxy-2-(Trifluoromethyl)Phenylacetic Acid
CAS No.	1214361-90-6
Molecular Formula	C10H9F3O3
Molecular Weight	234.17 g/mol
Synonyms	2-(5-Methoxy-2-(trifluoromethyl)phenyl)acetic acid; [5-Methoxy-2-(trifluoromethyl)phenyl]acetic Acid; 5-Methoxy-α-tolyl-2-trifluoromethylacetic Acid; 2-(5-Methoxy-2-trifluoromethylphenyl)acetic Acid; 5-Methoxy-2-trifluoromethylphenylacetic Acid; α-(5-Methoxy-2-(trifluoromethyl)phenyl)acetic Acid
EINECS	Contact for details

Quality Control

Our 5-Methoxy-2-(trifluoromethyl)phenylacetic acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most critical synthesis stages.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.