Description

2-(3-Fluorophenyl)-Isonicotinic Acid is a high-purity fluorinated heterocyclic building block of significant interest in advanced organic synthesis. Its core value lies in its unique molecular architecture, which combines a fluorinated phenyl ring with an isonicotinic acid moiety, making it a versatile intermediate for constructing complex molecules. This compound is primarily needed by research institutions and pharmaceutical companies engaged in the development of new active pharmaceutical ingredients (APIs), agrochemicals, and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders and anti-inflammatory pathways.
• Agrochemical Research: Used in the development of next-generation herbicides and fungicides, where the fluorine atom can enhance biological activity and environmental stability.
• Ligand Synthesis: Serves as a building block for creating sophisticated ligands used in catalysis and metal-organic frameworks (MOFs).
• Material Science: Incorporated into the design of advanced polymers and liquid crystals to modify their electronic and physical properties.
• Chemical Biology Probes: Utilized in the creation of fluorescent tags and molecular probes for studying biological processes.
• Custom Synthesis: Employed by contract research and manufacturing organizations (CROs/CMOs) for bespoke synthesis projects requiring fluorinated aromatic acids.

Basic Information

Product Name	2-(3-Fluorophenyl)-Isonicotinic Acid
CAS No.	1214350-69-2
Molecular Formula	C12H8FNO2
Molecular Weight	217.20 g/mol
Synonyms	2-(3-Fluorophenyl)pyridine-4-carboxylic acid; 4-Pyridinecarboxylic acid, 2-(3-fluorophenyl)-; Isonicotinic acid, 2-(3-fluorophenyl)-; 2-(3-Fluorophenyl)isonicotinate; 3-Fluoro-2-pyridin-4-ylbenzoic acid (tautomeric form)
EINECS	Contact for details

Quality Control

Our 2-(3-Fluorophenyl)-Isonicotinic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support compliance with relevant guidelines for pharmaceutical intermediates (ICH Q7).

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single unknown impurity	≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.