Description

2-Chloro-6-(Trifluoromethyl)Benzoic Acid Ethyl Ester is a high-value fluorinated aromatic building block essential for advanced organic synthesis. Its molecular structure, featuring both chloro and trifluoromethyl substituents, makes it a critical intermediate for introducing lipophilicity and metabolic stability into target molecules. This compound is primarily sought by R&D and process chemistry teams in the pharmaceutical and agrochemical industries for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key synthon for the preparation of active pharmaceutical ingredients (APIs), particularly in drug discovery programs targeting CNS disorders, inflammation, and oncology.
• Agrochemical Synthesis: Serves as a precursor in the manufacture of modern herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity.
• Liquid Crystal & OLED Materials: Used in the synthesis of fluorinated components for electronic display materials and organic light-emitting diodes (OLEDs).
• Advanced Polymer Chemistry: Acts as a monomer or modifier in the production of specialty polymers with unique chemical resistance and thermal properties.
• Chemical Research & Development: A versatile reagent in academic and industrial labs for methodology development and creating complex molecular architectures.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of bespoke compounds and scaled-up processes under cGMP conditions.

Basic Information

Product Name	2-Chloro-6-(Trifluoromethyl)Benzoic Acid Ethyl Ester
CAS No.	1214346-36-7
Molecular Formula	C10H8ClF3O2
Molecular Weight	252.62 g/mol
Synonyms	Ethyl 2-Chloro-6-(trifluoromethyl)benzoate; Benzoic acid, 2-chloro-6-(trifluoromethyl)-, ethyl ester; 2-Chloro-α,α,α-trifluoro-o-toluic acid ethyl ester; Ethyl 2-chloro-α,α,α-trifluoro-o-toluate; o-Chloro-α,α,α-trifluorotoluic acid ethyl ester
EINECS	Contact for details

Quality Control

Our 2-Chloro-6-(Trifluoromethyl)Benzoic Acid Ethyl Ester is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency. We provide Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment supports applications requiring high-purity intermediates for GLP and cGMP compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥98.0%
Purity (GC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.