Description

Methyl 3,6-Difluoro-2-Hydroxybenzoate is a high-purity fluorinated aromatic ester building block, valued for its unique substitution pattern that enables precise molecular modifications. This compound is critical for synthesizing advanced pharmaceutical intermediates and agrochemicals, where the introduction of fluorine atoms is key to enhancing biological activity and metabolic stability. It is primarily sought by R&D chemists and process development scientists in the life sciences and specialty chemical sectors.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in fluorinated drug candidates targeting CNS disorders and oncology.
• Agrochemical Synthesis: Used in the research and production of next-generation herbicides and fungicides, where the difluoro-hydroxybenzoate moiety contributes to improved efficacy and environmental profile.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated components in electronic display materials, enhancing thermal stability and optical properties.
• Polymer Modification: Employed to introduce fluorine-containing side chains into specialty polymers, improving their chemical resistance and surface characteristics.
• Organic Synthesis Building Block: Utilized in cross-coupling reactions, esterifications, and functional group transformations in complex molecule construction for research and scale-up.

Basic Information

Product Name	Methyl 3,6-Difluoro-2-Hydroxybenzoate
CAS No.	1214324-50-1
Molecular Formula	C8H6F2O3
Molecular Weight	188.13 g/mol
Synonyms	3,6-Difluoro-2-hydroxybenzoic acid methyl ester; Methyl 2-hydroxy-3,6-difluorobenzoate; 2-Hydroxy-3,6-difluorobenzoic acid methyl ester; Benzoic acid, 2-hydroxy-3,6-difluoro-, methyl ester; Methyl 3,6-difluoro-2-hydroxybenzoate; 3,6-Difluoro-2-methoxycarbonylphenol
EINECS	Contact for details

Quality Control

Our Methyl 3,6-Difluoro-2-Hydroxybenzoate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, supporting your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong bases and oxidizing agents. The compound is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.