Description

4-((1S)-1-Aminoethyl)-2-Fluorobenzoic Acid is a high-purity, chiral fluorinated benzoic acid derivative, serving as a critical building block in advanced pharmaceutical synthesis. Its value lies in the precise stereochemistry and fluorine substitution, which are essential for modulating the biological activity, metabolic stability, and pharmacokinetic properties of drug candidates. This compound is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel therapeutics, particularly in areas such as oncology, CNS disorders, and targeted protein degradation.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the synthesis of active pharmaceutical ingredients (APIs) and investigational new drugs.
• Proteolysis-Targeting Chimera (PROTAC) Development: Used in constructing linker-warhead components for targeted protein degradation therapies.
• Medicinal Chemistry Research: Enables structure-activity relationship (SAR) studies by introducing fluorine and a chiral amine handle into molecular scaffolds.
• Peptidomimetic Synthesis: Serves as a non-natural amino acid analog for creating modified peptides with enhanced stability.
• Ligand Discovery: Applied in fragment-based drug discovery and the development of enzyme inhibitors or receptor modulators.
• Chemical Biology Probes: Utilized in the design and synthesis of fluorescent or affinity tags for studying biological pathways.

Basic Information

Product Name	4-((1S)-1-Aminoethyl)-2-Fluorobenzoic Acid
CAS No.	1213659-26-7
Molecular Formula	C9H10FNO2
Molecular Weight	183.18 g/mol
Synonyms	(S)-4-(1-Aminoethyl)-2-fluorobenzoic Acid; 2-Fluoro-4-[(1S)-1-aminoethyl]benzoic Acid; Benzoic acid, 4-[(1S)-1-aminoethyl]-2-fluoro-; (1S)-1-(4-Carboxy-3-fluorophenyl)ethanamine; (S)-1-(4-Carboxy-3-fluorophenyl)ethylamine; 4-[(S)-1-Aminoethyl]-2-fluorobenzoic Acid; (S)-4-(1-Aminoethyl)-2-fluorobenzoic acid
EINECS	Contact for details

Quality Control

Our 4-((1S)-1-Aminoethyl)-2-Fluorobenzoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with stringent research and pharmaceutical-grade standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after use to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.