Description

2-(Difluoromethoxy)Isonicotinic Acid is a specialized fluorinated pyridine derivative that serves as a critical building block in advanced organic synthesis. Its unique difluoromethoxy-substituted isonicotinic acid structure makes it a valuable intermediate for creating novel compounds with enhanced biological activity and metabolic stability. This high-purity intermediate is primarily sought by research and development teams in the pharmaceutical and agrochemical sectors. It enables the synthesis of next-generation active ingredients targeting a range of therapeutic and crop protection applications.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and anti-infective drug candidates.
• Agrochemical Research: Used in developing new-generation herbicides and fungicides, where the difluoromethoxy group can improve lipophilicity and systemic activity in plants.
• Ligand & Catalyst Development: Serves as a functionalized pyridine ligand for constructing metal-organic complexes and catalysts used in asymmetric synthesis.
• Material Science: Building block for creating specialty polymers and liquid crystal materials that require fluorinated aromatic components for specific electronic or surface properties.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes and tags for studying enzyme function and biological pathways.

Basic Information

Product Name	2-(Difluoromethoxy)Isonicotinic Acid
CAS No.	1211581-51-9
Molecular Formula	C8H5F2NO3
Molecular Weight	201.13 g/mol
Synonyms	2-(Difluoromethoxy)isonicotinic acid; 2-(Difluoromethoxy)-4-pyridinecarboxylic acid; 4-Pyridinecarboxylic acid, 2-(difluoromethoxy)-; Isonicotinic acid, 2-(difluoromethoxy)-; 1211581-51-9; DFM-isonicotinic acid
EINECS	Contact for details

Quality Control

Our 2-(Difluoromethoxy)Isonicotinic Acid is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. We provide comprehensive quality assurance, with each lot accompanied by a detailed Certificate of Analysis (COA) that includes results for identity, purity, and impurity profiles. Our standard grade meets typical research and development requirements, and we can support custom synthesis to meet specific project specifications, including cGMP standards for advanced pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.