Description

4-(Trifluoromethyl)Oxazole-2-Carboxylic Acid is a high-value fluorinated heterocyclic building block essential for advanced organic synthesis. This compound is prized for its ability to introduce both the oxazole pharmacophore and a metabolically stable trifluoromethyl group into target molecules. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the creation of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of new drug candidates, particularly in medicinal chemistry programs targeting kinase inhibitors, anti-infectives, and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the trifluoromethyl group enhances biological activity and environmental stability.
• Material Science Research: Serves as a precursor for specialty polymers, liquid crystals, and other functional materials requiring fluorinated heterocyclic components.
• Chemical Biology & Proteomics: Employed as a building block for activity-based probes and other tools used to study enzyme function and biological pathways.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for use in custom synthesis projects and scale-up campaigns.

Basic Information

Product Name	4-(Trifluoromethyl)Oxazole-2-Carboxylic Acid
CAS No.	1211580-23-2
Molecular Formula	C5H2F3NO3
Molecular Weight	181.07 g/mol
Synonyms	2-Oxazolecarboxylic acid, 4-(trifluoromethyl)-; 4-(Trifluoromethyl)-1,3-oxazole-2-carboxylic acid; 4-Trifluoromethyloxazole-2-carboxylic acid; 4-TFM-oxazole-2-carboxylic acid; 1211580-23-2; Oxazole-2-carboxylic acid, 4-(trifluoromethyl)-; 4-(Trifluoromethyl)oxazole-2-carboxylate
EINECS	Contact for details

Quality Control

Every batch of 4-(Trifluoromethyl)Oxazole-2-Carboxylic Acid is manufactured and tested under strict quality management protocols. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for research and development. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles by HPLC, NMR, and MS is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its acidic nature, keep away from strong bases and incompatible materials. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.