Description

3-(Difluoromethoxy)Picolinic Acid is a high-purity, advanced pharmaceutical intermediate characterized by its unique difluoromethoxy-substituted picolinic acid structure. This compound is of significant commercial importance for its role in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring specific fluorine chemistry. It is primarily sought after by research institutions and manufacturers in the global pharmaceutical and agrochemical industries for developing next-generation compounds.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex drug molecules, especially those targeting metabolic and inflammatory pathways.
• Agrochemical Research: Used in the development of new herbicides and pesticides, where the difluoromethoxy group can enhance biological activity and stability.
• Ligand Synthesis: Serves as a precursor for creating specialized ligands used in catalysis and material science.
• Chemical Biology Probes: Utilized in the design of molecular probes for studying enzyme function and biological mechanisms.
• Fluorine Chemistry Studies: An important compound for academic and industrial research focused on incorporating fluorine atoms into organic molecules.

Basic Information

Product Name	3-(Difluoromethoxy)Picolinic Acid
CAS No.	1211541-12-6
Molecular Formula	C7H5F2NO3
Molecular Weight	189.12 g/mol
Synonyms	2-Pyridinecarboxylic acid, 3-(difluoromethoxy)-; 3-(Difluoromethoxy)pyridine-2-carboxylic acid; 3-DFMPA; Difluoromethoxypicolinic Acid; 3-(Difluoromethoxy)-2-pyridinecarboxylic acid; 3-(Difluoromethoxy)picolinate; Picolinic acid, 3-(difluoromethoxy)-
EINECS	Contact for details

Quality Control

Our 3-(Difluoromethoxy)Picolinic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical R&D and production. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (HPLC, Area %)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.