Description

Methyl 2-(Chlorosulfonyl)-3-Fluorobenzoate is a high-value, multi-functional chemical intermediate characterized by its reactive chlorosulfonyl and ester groups on a fluorinated aromatic ring. This compound is essential for the synthesis of advanced molecules, particularly in the pharmaceutical and agrochemical sectors, where its structure enables precise molecular modifications. It is primarily sought after by R&D chemists and process development teams in fine chemical manufacturing for creating novel active ingredients and complex organic compounds.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), especially those containing sulfonamide or sulfonyl fluoride moieties for targeted therapies.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, leveraging the fluorine atom for enhanced bioactivity and environmental stability.
• Material Science Precursor: Serves as a monomer or cross-linking agent in the production of specialty polymers and advanced materials with specific surface properties.
• Chemical Research & Development: A versatile reagent in organic synthesis for introducing the 2-(chlorosulfonyl)-3-fluorobenzoate group into complex molecular architectures.
• Ligand and Catalyst Development: Employed in the creation of novel ligands and organocatalysts for asymmetric synthesis and other catalytic processes.

Basic Information

Product Name	Methyl 2-(Chlorosulfonyl)-3-Fluorobenzoate
CAS No.	1211528-49-2
Molecular Formula	C8H6ClFO4S
Molecular Weight	252.64 g/mol
Synonyms	Methyl 3-Fluoro-2-(chlorosulfonyl)benzoate; Benzoic acid, 2-(chlorosulfonyl)-3-fluoro-, methyl ester; 3-Fluoro-2-(chlorosulfonyl)benzoic acid methyl ester; Methyl 3-fluoro-2-chlorosulfonylbenzoate; 2-(Chlorosulfonyl)-3-fluorobenzoic Acid Methyl Ester
EINECS	Contact for details

Quality Control

Every batch of Methyl 2-(Chlorosulfonyl)-3-Fluorobenzoate is manufactured and tested under a strict quality management system to ensure consistency and reliability for your critical syntheses. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as purity, identity, and impurity profiles. Our quality commitment aligns with cGMP principles where applicable, ensuring the material meets the stringent requirements for use in pharmaceutical and advanced chemical research.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under dry conditions to prevent degradation. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.