Description

3,3-Difluoro-3-Phenyl-2-Oxopropionic Acid Monohydrate is a high-purity fluorinated building block essential for advanced organic synthesis. This compound is valued for its unique difluoromethylenated α-keto acid structure, which serves as a versatile precursor in the development of pharmaceuticals and agrochemicals. It is primarily sought by research institutions and industrial manufacturers engaged in creating novel active ingredients, particularly in medicinal chemistry for protease inhibitor research and the synthesis of complex bioactive molecules.

Application

• Pharmaceutical Intermediate: A key synthon for the preparation of fluorinated drug candidates, especially protease inhibitors and enzyme modulators.
• Agrochemical Research: Used in the synthesis of novel, fluorinated pesticides and herbicides to enhance biological activity and environmental stability.
• Chemical Biology Probes: Serves as a precursor for fluorinated analogs of natural products and activity-based probes for studying enzyme function.
• Material Science: Potential building block for specialty polymers and advanced materials where fluorine incorporation modifies surface properties.
• Academic & Contract Research: Employed in method development and discovery chemistry within university and CRO laboratories.

Basic Information

Product Name	3,3-Difluoro-3-Phenyl-2-Oxopropionic Acid Monohydrate
CAS No.	1210714-06-9
Molecular Formula	C9H6F2O4 • H2O
Molecular Weight	216.15 g/mol
Synonyms	3,3-Difluoro-3-phenylpyruvic acid monohydrate; 2-Oxo-3,3-difluoro-3-phenylpropanoic acid monohydrate; α-Keto-3,3-difluoro-3-phenylpropionic acid hydrate; Difluorophenylpyruvic acid monohydrate; 3-Phenyl-3,3-difluoropyruvic acid hydrate; (3,3-Difluoro-3-phenyl-2-oxopropanoic acid) monohydrate; DFPPA monohydrate
EINECS	Contact for details

Quality Control

Our 3,3-Difluoro-3-Phenyl-2-Oxopropionic Acid Monohydrate is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing including HPLC, NMR, and Karl Fischer titration to ensure identity, purity, and consistency. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We support cGMP compliance for pharmaceutical applications and can tailor purity grades to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	7.0% - 9.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.