Description

Benzoic Acid, 2-Fluoro-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-, Ethyl Ester is a high-value, multi-functional boronic ester derivative, serving as a critical synthetic intermediate in advanced organic chemistry. Its core value lies in enabling precise carbon-carbon bond formation via Suzuki-Miyaura cross-coupling reactions, a cornerstone of modern pharmaceutical and materials science research. This compound is essential for R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries who require reliable, high-purity building blocks for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for fluorinated and boron-containing drug candidates targeting various therapeutic areas.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, leveraging the fluorine and boronate functional groups for enhanced bioactivity and stability.
• Material Science Precursor: Employed in the creation of organic electronic materials, such as organic light-emitting diodes (OLEDs) and semiconductors, where its structure allows for fine-tuning of electronic properties.
• Cross-Coupling Reactions: Primarily utilized in palladium-catalyzed Suzuki-Miyaura cross-coupling to efficiently introduce the substituted benzoic acid ester moiety into more complex molecules.
• Chemical Biology Probes: Serves as a versatile handle for bioconjugation and the development of chemical probes for studying biological processes and target engagement.
• Ligand and Catalyst Development: Acts as a precursor for synthesizing novel ligands and organometallic catalysts used in asymmetric synthesis and other catalytic transformations.

Basic Information

Product Name	Benzoic Acid, 2-Fluoro-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-, Ethyl Ester
CAS No.	1198615-86-9
Molecular Formula	C₁₇H₂₄BFO₄
Molecular Weight	322.18 g/mol
Synonyms	Ethyl 2-Fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate; 2-Fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoic Acid Ethyl Ester; 3-Pinacolatoboryl-2-fluorobenzoic Acid Ethyl Ester; 2-Fluoro-3-(pinacolatoboryl)benzoic Acid Ethyl Ester; 1198615-86-9; Ethyl 2-Fluoro-3-(pinacolboronato)benzoate; Benzoic acid, 2-fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-, ethyl ester
EINECS	Contact for details

Quality Control

Our Benzoic Acid, 2-Fluoro-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-, Ethyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and structural integrity suitable for sensitive cross-coupling applications. Certificates of Analysis (COA) with detailed chromatographic data are provided to support your R&D and quality assurance processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, the container should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Recommended long-term storage temperature is 2-8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.