Description

Methyl 4-Bromo-2,5-Difluorobenzoate is a high-purity fluorinated aromatic ester building block of significant importance in advanced organic synthesis. Its core value lies in its versatile reactivity, where the bromine and fluorine substituents serve as orthogonal handles for selective cross-coupling and functional group transformations. This compound is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the construction of complex molecules, particularly in the development of active pharmaceutical ingredients (APIs) and novel crop protection agents.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of fluorinated drug candidates, leveraging the bromine for Suzuki or Buchwald-Hartwig couplings.
• Agrochemical Research: Used in creating novel, fluorinated herbicides, fungicides, and insecticides where the difluoro motif enhances bioavailability and metabolic stability.
• Material Science Precursor: Serves as a monomer or building block for synthesizing specialty polymers and liquid crystals with tailored electronic properties.
• Organic Synthesis Building Block: Employed in palladium-catalyzed cross-coupling reactions and nucleophilic aromatic substitution (SNAr) to introduce complex aromatic systems.
• Chemical Biology Probe Development: Utilized in the synthesis of fluorinated probes and tags for imaging and diagnostic applications.

Basic Information

Product Name	Methyl 4-Bromo-2,5-Difluorobenzoate
CAS No.	1193162-21-8
Molecular Formula	C8H5BrF2O2
Molecular Weight	251.03 g/mol
Synonyms	4-Bromo-2,5-difluorobenzoic acid methyl ester; Methyl 4-bromo-2,5-difluorobenzoate; Benzoic acid, 4-bromo-2,5-difluoro-, methyl ester; 2,5-Difluoro-4-bromobenzoic acid methyl ester; Methyl 2,5-difluoro-4-bromobenzoate
EINECS	Contact for details

Quality Control

Our production of Methyl 4-Bromo-2,5-Difluorobenzoate adheres to stringent quality protocols to ensure batch-to-batch consistency and reliability for critical R&D and scale-up processes. Each lot is characterized by advanced analytical techniques including HPLC, GC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, handling and storage should minimize exposure to direct light.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Heavy Metals	< 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.