Description

2-Fluoro-5-(4-Trifluoromethoxyphenyl)Benzoic Acid is a high-value, multi-functional aromatic carboxylic acid derivative, distinguished by its unique trifluoromethoxy and fluorine substituents. This compound serves as a critical advanced pharmaceutical intermediate and a versatile building block for the synthesis of complex organic molecules. It is primarily required by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in drug discovery programs targeting CNS disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, where the fluorine and trifluoromethoxy groups enhance biological activity and metabolic stability.
• Liquid Crystal & OLED Material Precursor: Serves as a core structure in the development of advanced electronic materials for displays and lighting applications.
• Organic Synthesis Building Block: A versatile reagent for Suzuki-Miyaura and other cross-coupling reactions to construct complex biaryl systems.
• Chemical Research & Development: Essential for academic and industrial research exploring new fluorinated compounds and their properties.
• Custom Synthesis & Contract Manufacturing: Supplied for bespoke synthesis projects requiring high-purity, specialized fluorinated intermediates.

Basic Information

Product Name	2-Fluoro-5-(4-Trifluoromethoxyphenyl)Benzoic Acid
CAS No.	1178497-48-7
Molecular Formula	C14H8F4O3
Molecular Weight	300.21 g/mol
Synonyms	[4'-(Trifluoromethoxy)-[1,1'-biphenyl]-3-carboxylic acid, 2-fluoro-]; 2-Fluoro-5-[4-(trifluoromethoxy)phenyl]benzoic Acid; 2-Fluoro-5-(4-trifluoromethoxyphenyl)benzoic acid; 3-Carboxy-4-fluoro-4'-(trifluoromethoxy)biphenyl; 1178497-48-7; BRN 19128035
EINECS	Contact for details

Quality Control

Our production of 2-Fluoro-5-(4-Trifluoromethoxyphenyl)Benzoic Acid adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) documenting all critical parameters are provided with each shipment. We support cGMP compliance for pharmaceutical applications and can tailor quality specifications to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, open flames, and incompatible materials. The container should be kept tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Standard Grade)
Purity (HPLC)	≥ 99.0% (High Purity Grade)
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.