Description

Methyl 4-Amino-3,5-Difluorobenzoate is a high-purity fluorinated aromatic building block of significant importance in advanced organic synthesis. This compound is valued for its role as a key intermediate in the development of active pharmaceutical ingredients (APIs) and agrochemicals, where the introduction of fluorine atoms is critical for modulating biological activity and metabolic stability. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of novel drug candidates, particularly in kinase inhibitors, anti-cancer agents, and CNS-active compounds.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides, where the difluoro-substituted benzoate moiety enhances efficacy.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated components in electronic display materials and organic light-emitting diodes (OLEDs).
• Polymer & Resin Modifiers: Incorporated into specialty polymers to impart specific chemical resistance, thermal stability, or surface properties.
• Chemical Research & Development: Employed in academic and industrial labs for methodological studies in cross-coupling reactions and fluorination chemistry.
• Dye & Pigment Intermediate: Acts as a starting material for synthesizing specialized fluorinated dyes and pigments.

Basic Information

Product Name	Methyl 4-Amino-3,5-Difluorobenzoate
CAS No.	1162676-00-7
Molecular Formula	C8H7F2NO2
Molecular Weight	187.14 g/mol
Synonyms	4-Amino-3,5-difluorobenzoic acid methyl ester; Methyl 4-amino-3,5-difluorobenzoate; Benzoic acid, 4-amino-3,5-difluoro-, methyl ester; 3,5-Difluoro-4-aminobenzoic acid methyl ester; Methyl 3,5-difluoro-4-aminobenzoate; 4-Amino-3,5-difluorobenzoic acid, methyl ester; Methyl 4-amino-3,5-difluorobenzoate CAS 1162676-00-7
EINECS	Contact for details

Quality Control

Our Methyl 4-Amino-3,5-Difluorobenzoate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with each shipment. We support custom synthesis and can tailor specifications to meet specific project requirements, including compliance with ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.