Description

4-Chloro-3,5-Difluorobenzoic Acid is a high-purity, multi-functional aromatic carboxylic acid derivative distinguished by its specific halogen substitution pattern. This compound serves as a critical advanced pharmaceutical intermediate (API) and a versatile building block in modern synthetic chemistry. It is primarily utilized by R&D chemists and process engineers in the pharmaceutical, agrochemical, and specialty chemical industries for the development of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for constructing complex molecules in drug discovery and development, particularly for candidates targeting CNS disorders and metabolic diseases.
• Agrochemical Synthesis: Used in the production of advanced herbicides and fungicides, where the difluoro and chloro substituents contribute to biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorine-containing monomers used in electronic display technologies and organic light-emitting diodes (OLEDs).
• Polymer Modification: Acts as a functional monomer or cross-linking agent to introduce aromaticity and halogen functionality into specialty polymers.
• Organic Synthesis Building Block: Employed in Suzuki, Sonogashira, and other cross-coupling reactions to introduce the benzoic acid moiety with specific halogen handles for further derivatization.
• Material Science Research: Used in the development of metal-organic frameworks (MOFs) and other porous materials due to its rigid aromatic structure and potential coordination sites.

Basic Information

Product Name	4-Chloro-3,5-Difluorobenzoic Acid
CAS No.	1160573-19-2
Molecular Formula	C7H3ClF2O2
Molecular Weight	192.55 g/mol
Synonyms	3,5-Difluoro-4-chlorobenzoic Acid; Benzoic acid, 4-chloro-3,5-difluoro-; 4-Chloro-3,5-difluorobenzoic acid; 1160573-19-2; 4-Chloro-3,5-difluoro-benzoic acid; 3,5-Difluoro-4-chloro-benzoic acid; 4-Chloro-3,5-difluorobenzoic acid (CAS 1160573-19-2)
EINECS	Contact for details

Quality Control

Our 4-Chloro-3,5-Difluorobenzoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment ensures the material is suitable for demanding applications in GMP-oriented pharmaceutical development and other critical industrial processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong bases, strong oxidizing agents, and sources of ignition. The container should be kept tightly sealed to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.