Description

Basmisanil CAS NO 1159600-41-5 is a high-purity, non-benzodiazepine compound belonging to the class of α5-GABAA receptor negative allosteric modulators (NAMs). This compound is of significant interest for its targeted mechanism of action in central nervous system research and development. It is primarily utilized by pharmaceutical R&D teams and academic researchers focused on cognitive disorders and neurological conditions. Our supply ensures the consistent quality and reliability required for critical preclinical and analytical work.

Application

• Pharmaceutical Reference Standard: Serves as a primary standard for analytical method development, validation, and quality control in API manufacturing.
• Preclinical Neuroscience Research: Used in vitro and in vivo studies to investigate the role of α5-GABAA receptors in cognitive function and memory.
• Drug Discovery & Development: A key intermediate or active candidate in the synthesis and screening of novel therapeutics for cognitive enhancement and related disorders.
• Biochemical Assay Development: Employed as a selective ligand in high-throughput screening (HTS) and binding assays to identify new modulators.
• Metabolite Identification & Pharmacokinetics: Used in ADME (Absorption, Distribution, Metabolism, Excretion) studies to understand the compound's metabolic profile.
• Academic & Institutional Research: Supports fundamental research into GABAergic signaling pathways and their implications for brain health and disease.

Basic Information

Product Name	Basmisanil
CAS No.	1159600-41-5
Molecular Formula	C20H17FN4O2
Molecular Weight	364.38 g/mol
Synonyms	RG1662; RO5186582; N-[(2,6-Difluorophenyl)methyl]-2-[(2-fluorophenyl)methyl]-6,7-dimethoxy-4-quinazolinamine; Basmisanil (RG1662); α5-GABAA NAM; RO-5186582; 6,7-Dimethoxy-2-[(2-fluorobenzyl)amino]-N-(2,6-difluorobenzyl)quinazolin-4-amine
EINECS	Contact for details

Quality Control

Every batch of Basmisanil is manufactured and analyzed under strict quality management systems. We provide comprehensive analytical data to support your regulatory and research requirements. A detailed Certificate of Analysis (COA) is supplied with each shipment, confirming identity, purity, and impurity profiles as determined by advanced chromatographic and spectroscopic techniques. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates and reference standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the original container is sealed tightly after each use to minimize exposure to atmospheric humidity. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥98.0%
Related Substances (HPLC)	Individual impurity: ≤0.5% Total impurities: ≤2.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.