Description

2-(2,5-Difluorophenyl)Cyclopropanecarboxylic Acid is a high-value fluorinated cyclopropane derivative, serving as a critical chiral building block in advanced organic synthesis. Its unique structure, featuring a cyclopropane ring and difluorophenyl moiety, enables the precise modulation of molecular properties, making it indispensable for developing novel active compounds. This intermediate is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the creation of new drug candidates and crop protection agents.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new Active Pharmaceutical Ingredients (APIs), particularly in medicinal chemistry programs targeting CNS disorders, oncology, and metabolic diseases.
• Agrochemical Synthesis: Used in the design and synthesis of novel herbicides, fungicides, and insecticides, where the fluorinated cyclopropane structure can enhance biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for constructing sophisticated chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the synthesis of specialty polymers and advanced organic materials where fluorinated components are required to alter electronic properties or stability.
• Chemical Biology Probes: Utilized as a building block for creating molecular probes to study enzyme function and biological pathways.

Basic Information

Product Name	2-(2,5-Difluorophenyl)Cyclopropanecarboxylic Acid
CAS No.	1157698-34-4
Molecular Formula	C10H8F2O2
Molecular Weight	198.17 g/mol
Synonyms	2-(2,5-Difluorophenyl)cyclopropanecarboxylic acid; 2-(2,5-Difluorophenyl)cyclopropane-1-carboxylic acid; Cyclopropanecarboxylic acid, 2-(2,5-difluorophenyl)-; 1-Carboxy-2-(2,5-difluorophenyl)cyclopropane; (1R,2S)-rel-2-(2,5-Difluorophenyl)cyclopropanecarboxylic acid (for chiral forms); 2,5-Difluorophenylcyclopropanecarboxylic acid
EINECS	Contact for details

Quality Control

Every batch of 2-(2,5-Difluorophenyl)Cyclopropanecarboxylic Acid is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the product meets the high-purity standards required for research and process development. A detailed Certificate of Analysis (COA), including chiral purity (enantiomeric excess) where applicable, chromatographic purity (HPLC), and structural confirmation (NMR, IR), is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong bases and oxidizing agents. For long-term storage, consider inert gas purging to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	Contact for details
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.