Description

2-(3-Fluoro-Phenyl)-Cyclopropanecarboxylic Acid is a high-purity fluorinated cyclopropane derivative, a crucial building block in modern synthetic organic chemistry. Its value lies in its unique structural motif, which combines the constrained geometry of the cyclopropane ring with the electronic influence of the fluorine atom, making it an essential intermediate for creating novel compounds with targeted biological activity. This compound is primarily needed by research institutions and pharmaceutical companies engaged in the development of new active pharmaceutical ingredients (APIs), agrochemicals, and advanced materials.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of drug candidates, particularly in medicinal chemistry programs targeting central nervous system (CNS) disorders, inflammation, and metabolic diseases.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides, where the fluorinated cyclopropane structure can enhance bioavailability and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands or organocatalysts used in asymmetric synthesis, leveraging the stereogenic center of the cyclopropane ring.
• Material Science Precursor: Employed in the synthesis of specialty polymers and liquid crystals, where the fluorine atom can impart desired dielectric and surface properties.
• Chemical Biology Probe Synthesis: Utilized to create molecular probes for studying enzyme function and protein-ligand interactions due to its potential as a bioisostere.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds at various scales, from research to pilot plant.

Basic Information

Product Name	2-(3-Fluoro-Phenyl)-Cyclopropanecarboxylic Acid
CAS No.	1157561-41-5
Molecular Formula	C10H9FO2
Molecular Weight	180.18 g/mol
Synonyms	2-(3-Fluorophenyl)cyclopropanecarboxylic acid; 1-(3-Fluorophenyl)cyclopropane-1-carboxylic acid; 3-Fluorophenylcyclopropanecarboxylic acid; (3-Fluorophenyl)cyclopropanecarboxylic acid; 2-(3-Fluorophenyl)cyclopropanecarboxylic acid; Cyclopropanecarboxylic acid, 2-(3-fluorophenyl)-; 1157561-41-5; 2-(3-Fluorophenyl)cyclopropane-1-carboxylic acid
EINECS	Contact for details

Quality Control

Our 2-(3-Fluoro-Phenyl)-Cyclopropanecarboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and KF titration for moisture content, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which can affect stability and handling properties. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.