Description

Methyl 4-(Difluoromethoxy)-3-Iodobenzoate is a high-purity, multi-functional organic building block essential for advanced chemical synthesis. Its unique structure, featuring both difluoromethoxy and iodo substituents on a benzoate core, makes it a critical intermediate for constructing complex molecules with tailored properties. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, metabolic diseases, and inflammation.
• Agrochemical Research: Used in the development of new-generation herbicides, fungicides, and insecticides, where the difluoromethoxy group can enhance metabolic stability and bioavailability.
• Ligand & Catalyst Development: Serves as a versatile scaffold for creating specialized ligands and organocatalysts used in asymmetric synthesis and cross-coupling reactions.
• Material Science Precursor: Employed in the research of advanced organic electronic materials, such as organic light-emitting diodes (OLEDs) and semiconductors, due to its halogenated aromatic structure.
• Custom Synthesis & Contract Manufacturing: A fundamental starting material for custom synthesis projects and scale-up processes in fine chemical production.
• Academic & Industrial R&D: Utilized in research laboratories for methodological studies in fluorination chemistry and palladium-catalyzed cross-coupling reactions like Suzuki or Sonogashira couplings.

Basic Information

Product Name	Methyl 4-(Difluoromethoxy)-3-Iodobenzoate
CAS No.	1131614-23-7
Molecular Formula	C9H7F2IO3
Molecular Weight	328.05 g/mol
Synonyms	3-Iodo-4-(difluoromethoxy)benzoic acid methyl ester; Methyl 3-iodo-4-(difluoromethoxy)benzoate; Benzoic acid, 4-(difluoromethoxy)-3-iodo-, methyl ester; 4-(Difluoromethoxy)-3-iodobenzoic Acid Methyl Ester; MFCD30533333
EINECS	Contact for details

Quality Control

Every batch of Methyl 4-(Difluoromethoxy)-3-Iodobenzoate is manufactured under strict quality management systems. We ensure high purity and batch-to-batch consistency through rigorous analytical protocols including HPLC, GC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Heavy Metals	< 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	< 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.