Description

2,4-Difluoro-3-Trifluoromethoxybenzoic Acid is a high-value, multi-fluorinated benzoic acid derivative characterized by its unique trifluoromethoxy and difluoro substitution pattern. This compound serves as a critical advanced pharmaceutical intermediate and building block for the synthesis of complex molecules. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries to introduce fluorine motifs that enhance the metabolic stability, bioavailability, and binding affinity of target compounds.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in oncology, CNS, and antiviral drug candidates.
• Agrochemical Synthesis: Used in the research and development of novel herbicides and fungicides, where the fluorine atoms improve lipophilicity and biological activity.
• Liquid Crystal Materials: Serves as a precursor for fluorinated liquid crystal compounds used in advanced display technologies.
• Polymer Chemistry: Acts as a monomer or modifier for introducing fluorine into polymers to enhance chemical resistance, thermal stability, and surface properties.
• Organic Synthesis & Catalysis: Employed as a versatile reagent in cross-coupling reactions and as a ligand precursor in organometallic catalysis.
• Material Science Research: Used in the development of organic semiconductors and other electronic materials due to its electron-withdrawing characteristics.

Basic Information

Product Name	2,4-Difluoro-3-Trifluoromethoxybenzoic Acid
CAS No.	1119454-13-5
Molecular Formula	C8H3F5O3
Molecular Weight	242.10 g/mol
Synonyms	3-(Trifluoromethoxy)-2,4-difluorobenzoic Acid; 2,4-Difluoro-3-(trifluoromethoxy)benzoic Acid; Benzoic acid, 2,4-difluoro-3-(trifluoromethoxy)-; 2,4-Difluoro-α,α,α-trifluoro-m-anisic Acid; 2,4-Difluoro-3-trifluoromethoxy-benzoic Acid; 1119454-13-5; CAS 1119454-13-5
EINECS	Contact for details

Quality Control

Our 2,4-Difluoro-3-Trifluoromethoxybenzoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for advanced synthetic applications. Standard quality verification includes HPLC for assay and purity, NMR for structural confirmation, and Karl Fischer titration for moisture content. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong bases, strong oxidizing agents, and sources of ignition. Due to its nature as a strong acid/organic solvent, handle with appropriate personal protective equipment in a fume hood.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.