Description

Methyl 1-(3-Fluorophenyl)Cyclobutane-1-Carboxylate is a high-value fluorinated cyclobutane derivative, serving as a critical synthetic intermediate in advanced organic chemistry. Its unique structure, featuring a fluorinated aromatic ring fused to a strained cyclobutane carboxylate, makes it an essential building block for constructing complex molecules with tailored properties. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly for central nervous system (CNS) targets and enzyme inhibitors where the fluorophenyl moiety is crucial for bioactivity and metabolic stability.
• Agrochemical Research: Used in developing new generations of herbicides, fungicides, and pesticides, leveraging the fluorine atom to enhance lipophilicity and environmental persistence of active compounds.
• Material Science: Serves as a monomer or building block for specialty polymers and liquid crystals, where the rigid cyclobutane core contributes to thermal stability and specific optical properties.
• Chemical Synthesis: Employed in organic methodology development, including ring-opening reactions, cross-coupling, and as a scaffold for library synthesis in medicinal chemistry.
• Fluorine Chemistry: A valuable substrate for studying the effects of fluorine substitution on aromatic systems and for further functionalization to create more complex fluorinated architectures.

Basic Information

Item	Details
Product Name	Methyl 1-(3-Fluorophenyl)Cyclobutane-1-Carboxylate
CAS No.	1111470-96-2
Molecular Formula	C12H13FO2
Molecular Weight	208.23 g/mol
Synonyms	Methyl 1-(3-fluorophenyl)cyclobutanecarboxylate; 1-(3-Fluorophenyl)cyclobutanecarboxylic acid methyl ester; 3-Fluorophenyl cyclobutanecarboxylate methyl ester; Methyl 3-fluorophenylcyclobutanecarboxylate; 1-(m-Fluorophenyl)cyclobutanecarboxylic Acid Methyl Ester; Cyclobutanecarboxylic acid, 1-(3-fluorophenyl)-, methyl ester
EINECS	Contact for details

Quality Control

Our production of Methyl 1-(3-Fluorophenyl)Cyclobutane-1-Carboxylate adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical characterization, including HPLC, GC, NMR, and mass spectrometry. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment, ensuring full traceability and compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.