Description

3-Iodo-4-(Trifluoromethoxy)Benzoic Acid is a high-value, multi-functional aromatic building block characterized by its unique combination of iodine and trifluoromethoxy substituents. This compound is essential for advanced organic synthesis, enabling the introduction of both halogen and fluorine-containing groups into target molecules, which is critical for modulating their physicochemical and biological properties. It is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for applications in medicinal chemistry, material science, and the development of novel chemical entities.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, where the trifluoromethoxy group enhances lipophilicity and metabolic stability.
• Material Science Research: Acts as a monomer or functionalization agent in the creation of specialty polymers, liquid crystals, and organic electronic materials.
• Medicinal Chemistry & Drug Discovery: A versatile scaffold for constructing compound libraries via cross-coupling reactions (e.g., Suzuki, Sonogashira) to explore structure-activity relationships (SAR).
• Chemical Biology Probes: Utilized to develop molecular probes and tags for imaging and diagnostic applications, leveraging the reactivity of the iodine atom.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring specific halogenated benzoic acid derivatives.

Basic Information

Product Name	3-Iodo-4-(Trifluoromethoxy)Benzoic Acid
CAS No.	1110709-70-0
Molecular Formula	C8H4F3IO3
Molecular Weight	331.02 g/mol
Synonyms	3-Iodo-4-(trifluoromethoxy)benzoic acid; 4-(Trifluoromethoxy)-3-iodobenzoic acid; Benzoic acid, 3-iodo-4-(trifluoromethoxy)-; 3-Iodo-4-trifluoromethoxybenzoic acid; 1110709-70-0; 3-Iodo-α,α,α-trifluoro-p-anisic acid; 3-Iodo-4-(trifluoromethoxy)benzenecarboxylic acid
EINECS	Contact for details

Quality Control

Our 3-Iodo-4-(Trifluoromethoxy)Benzoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for research and process chemistry. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.