Description

Methyl 4-Amino-3-(Difluoromethoxy)Benzoate is a high-purity, synthetically valuable benzoate ester derivative, distinguished by its amino and difluoromethoxy functional groups. This compound serves as a critical pharmaceutical intermediate and advanced building block in organic synthesis, enabling the development of novel active ingredients. It is primarily sought by R&D and production teams in the pharmaceutical, agrochemical, and specialty chemical sectors for creating complex molecules with targeted biological activity.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, inflammation, and metabolic diseases.
• Agrochemical Synthesis: Building block for developing new-generation herbicides, fungicides, and insecticides, where the difluoromethoxy group can enhance metabolic stability and bioavailability.
• Organic Synthesis & Research: Versatile reagent for constructing complex heterocycles and fine chemicals in academic and industrial R&D laboratories.
• Material Science Precursor: Used in the development of specialty polymers and advanced organic materials requiring specific fluorine-containing motifs.
• Ligand & Catalyst Development: Serves as a starting material for synthesizing novel ligands and organocatalysts used in asymmetric synthesis.

Basic Information

Product Name	Methyl 4-Amino-3-(Difluoromethoxy)Benzoate
CAS No.	1096816-13-5
Molecular Formula	C9H9F2NO3
Molecular Weight	217.17 g/mol
Synonyms	Benzoic acid, 4-amino-3-(difluoromethoxy)-, methyl ester; Methyl 4-amino-3-(difluoromethoxy)benzoate; 3-(Difluoromethoxy)-4-aminobenzoic acid methyl ester; 4-Amino-3-(difluoromethoxy)methyl benzoate; Methyl 3-(difluoromethoxy)-4-aminobenzoate
EINECS	Contact for details

Quality Control

Our production of Methyl 4-Amino-3-(Difluoromethoxy)Benzoate adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and structural identity. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with agreed specifications. Our quality system is designed to support cGMP and ISO standards for traceability and consistency, making it suitable for regulated applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound may be hygroscopic; keep the container tightly sealed under an inert atmosphere if specified. Keep away from strong oxidizing agents and bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.