Description

(R)-Bendroflumethiazide is the single enantiomer form of the thiazide diuretic bendroflumethiazide. This specific stereoisomer is of significant interest in advanced pharmaceutical research and development for studying structure-activity relationships and developing novel therapeutic agents. It is primarily utilized by pharmaceutical R&D laboratories, analytical reference standard providers, and academic institutions engaged in chiral chemistry and cardiovascular drug discovery.

Application

• Pharmaceutical Reference Standard: Serves as a high-purity chiral standard for analytical method development, validation, and quality control in pharmaceutical testing.
• Chiral Intermediate: Used in the research and synthesis of novel enantiomerically pure drug candidates targeting diuretic and antihypertensive pathways.
• Metabolic and Pharmacokinetic Studies: Employed in preclinical research to investigate the specific biological activity, metabolism, and distribution of the (R)-enantiomer.
• Academic and Institutional Research: A key material for universities and research institutes studying stereochemistry, receptor binding, and the mechanistic actions of thiazide diuretics.

Basic Information

Product Name	(R)-Bendroflumethiazide
CAS No.	1087345-31-0
Molecular Formula	C15H14F3N3O4S2
Molecular Weight	421.41 g/mol
Synonyms	(R)-3-Benzyl-6-(trifluoromethyl)-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide; (R)-Bendrofluazide; (R)-Bendroflumethiazide; (R)-Benuron; (R)-Naturetin; (R)-Aprinox; (R)-BFTZ; (R)-Enantiomer of Bendroflumethiazide
EINECS	Contact for details

Quality Control

Our (R)-Bendroflumethiazide is produced under strict quality management systems to ensure high enantiomeric purity and chemical integrity, suitable for research applications. Each batch is accompanied by comprehensive analytical documentation, including HPLC/Chiral HPLC for purity and enantiomeric excess determination. Certificates of Analysis (COA) with detailed chromatographic data are available upon request to support your regulatory and research needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.