Description

2,6-Difluoro-3-(Trifluoromethyl)-Benzoic Acid is a high-value fluorinated aromatic building block characterized by its unique substitution pattern. This compound matters as a critical intermediate in modern synthetic chemistry, enabling the introduction of fluorine atoms and a carboxylic acid handle into complex molecular architectures. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in drug discovery programs targeting metabolic and central nervous system diseases.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides where the fluorine atoms enhance biological activity and environmental stability.
• Ligand and Catalyst Preparation: Serves as a precursor for creating specialized ligands and organocatalysts used in asymmetric synthesis and cross-coupling reactions.
• Material Science Research: Employed in the development of novel fluorinated polymers, liquid crystals, and organic electronic materials.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the global life sciences market.

Basic Information

Product Name	2,6-Difluoro-3-(trifluoromethyl)benzoic acid
CAS No.	1048921-49-8
Molecular Formula	C8H3F5O2
Molecular Weight	226.10 g/mol
Synonyms	3-(Trifluoromethyl)-2,6-difluorobenzoic Acid; 2,6-Difluoro-α,α,α-trifluoro-m-toluic Acid; Benzoic acid, 2,6-difluoro-3-(trifluoromethyl)-; 2,6-Difluoro-3-trifluoromethylbenzoic acid; 2,6-Difluoro-α,α,α-trifluoro-m-toluic Acid; 1048921-49-8
EINECS	Contact for details

Quality Control

Our production of 2,6-Difluoro-3-(trifluoromethyl)-Benzoic Acid adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with each shipment, documenting all critical quality attributes. Our quality system is designed to support cGMP (current Good Manufacturing Practice) requirements for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong bases, strong oxidizing agents, and sources of ignition. Due to its nature as a strong acid/organic solvent, handle with appropriate personal protective equipment and ensure compatibility of storage containers.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥98.0%
Purity (GC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.