Description

Entacapone (Sodium Salt) is the sodium salt form of the well-known catechol-O-methyltransferase (COMT) inhibitor, Entacapone. This compound is a critical pharmaceutical intermediate, valued for its enhanced solubility and stability profile compared to the free acid form. It is primarily required by manufacturers in the active pharmaceutical ingredient (API) and fine chemical sectors for the development and production of advanced Parkinson's disease therapeutics. The product is supplied under stringent quality controls to ensure consistency for demanding synthesis processes.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of Entacapone API for anti-Parkinson's medications.
• Reference Standard: Used in analytical laboratories for method development, validation, and quality control testing of drug substances and products.
• Research & Development: Serves as a crucial material in preclinical and clinical research for studying COMT inhibition and developing new neurological therapies.
• Formulation Development: Employed in the development of various drug delivery systems, such as fixed-dose combination tablets, due to its salt form properties.

Basic Information

Product Name	Entacapone (Sodium Salt)
CAS No.	1047659-02-8
Molecular Formula	C14H14N2NaO5
Molecular Weight	313.26 g/mol
Synonyms	(E)-2-Cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethyl-2-propenamide Sodium Salt; Entacapone Sodium; Entacapone Na; (2E)-2-Cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethylprop-2-enamide Sodium Salt; Comtan Impurity C Sodium Salt; OR-611 Sodium Salt
EINECS	Contact for details

Quality Control

Our Entacapone (Sodium Salt) is manufactured and tested under a quality management system. Each batch undergoes rigorous analytical testing to ensure it meets high-purity standards suitable for pharmaceutical development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	Yellow to orange-yellow powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.0%
Water Content (KF)	≤5.0%
Related Substances (HPLC)	Individual impurity: ≤0.5% Total impurities: ≤2.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.