Description

Difelikefalin is a potent and selective kappa opioid receptor (KOR) agonist, a synthetic peptide with significant therapeutic potential. Its primary value lies in its peripheral restriction, which minimizes central nervous system side effects while effectively targeting specific receptors involved in pruritus (itching) and pain pathways. This makes it a critical compound for pharmaceutical research and development, particularly for researchers and manufacturers developing novel treatments for chronic kidney disease-associated pruritus (CKD-aP) and other conditions. The product is supplied under the identifier CAS NO 1024828-77-0.

Application

• Active Pharmaceutical Ingredient (API) for the manufacture of injectable therapeutics targeting pruritus.
• Pharmaceutical R&D Reference Standard for method development, validation, and quality control in drug discovery and production.
• Preclinical and Clinical Research material for studying kappa opioid receptor pharmacology and peripheral analgesic mechanisms.
• Bulk Pharmaceutical Intermediate for the synthesis of finished dosage forms in cGMP environments.
• Biochemical Research tool for investigating G-protein coupled receptor (GPCR) signaling pathways.

Basic Information

Product Name	Difelikefalin
CAS No.	1024828-77-0
Molecular Formula	C₃₆H₅₁N₇O₆
Molecular Weight	665.84 g/mol
Synonyms	CR845; FE 202845; Difelikefalin Acetate; (2-D-Phenylalanyl-D-cystyl-D-lysyl-D-phenylalanyl-D-tryptophyl-D-lysyl-D-threonyl-D-phenylalanyl-D-cystine) cyclic (2→8),(5→11)-bis(disulfide); Korsuva; CR-845; FE-202845
EINECS	Contact for details

Quality Control

Our Difelikefalin is manufactured under strict quality management systems to ensure it meets the high standards required for pharmaceutical applications. Each batch is subjected to comprehensive analytical testing, including identity confirmation, purity assay, and impurity profiling via advanced techniques like HPLC and mass spectrometry. A Certificate of Analysis (COA) detailing all test results and specifications is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and potency. For long-term storage, consider desiccated environments.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Purity (HPLC, Total)	≥ 99.0%
Single Unknown Impurity	≤ 0.5%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.