Description

3,5-Difluoroisatoic Anhydride is a high-purity fluorinated heterocyclic building block essential for advanced organic synthesis. This compound is valued for its role as a key precursor in the development of complex molecules, particularly in the pharmaceutical and agrochemical sectors. It is primarily sought after by research chemists and process development scientists working on novel active ingredients, including kinase inhibitors and other fluorinated drug candidates. Its specific substitution pattern offers precise control over molecular architecture, enabling the fine-tuning of biological activity and physicochemical properties.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of fluorinated active pharmaceutical ingredients (APIs), especially kinase inhibitors and other targeted therapies.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and pesticides where the difluoro motif enhances bioavailability and stability.
• Material Science: Serves as a monomer or precursor for specialty polymers and advanced materials with unique electronic or surface properties.
• Chemical Synthesis: Employed in academic and industrial R&D for constructing complex heterocyclic scaffolds and fluorinated analogs of bioactive compounds.
• Ligand and Catalyst Development: Useful for creating novel chelating agents and organocatalysts used in asymmetric synthesis.

Basic Information

Product Name	3,5-Difluoroisatoic Anhydride
CAS No.	1022959-48-3
Molecular Formula	C8H3F2NO3
Molecular Weight	199.11 g/mol
Synonyms	3,5-Difluoro-1H-benzo[d][1,3]oxazine-2,4-dione; 3,5-Difluoro-2H-3,1-benzoxazine-2,4(1H)-dione; 3,5-Difluoroisatoic acid anhydride; 2,4-Dioxo-3,5-difluoro-1,4-dihydro-2H-3,1-benzoxazine; Isatoic Anhydride, 3,5-difluoro-; 3,5-Difluorobenzo[d][1,3]oxazine-2,4-dione
EINECS	Contact for details

Quality Control

Our 3,5-Difluoroisatoic Anhydride is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and KF titration for moisture content, to ensure it meets the stringent requirements of research and development applications. A detailed Certificate of Analysis (COA) is provided with each shipment, guaranteeing traceability and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.