Description

Pf-04457845 is a potent and selective small molecule inhibitor of fatty acid amide hydrolase (FAAH), an enzyme critical to the endocannabinoid signaling system. This compound is a vital research tool for investigating the therapeutic potential of FAAH inhibition in areas such as pain management, inflammation, and neurological disorders. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies engaged in preclinical drug discovery and neuropharmacology studies.

Application

• Pharmacological Research: A key reference standard and active probe for studying the endocannabinoid system, its role in neurotransmission, and related physiological pathways.
• Drug Discovery & Development: Used in high-throughput screening (HTS), target validation, and as a lead compound for developing novel FAAH-targeted therapeutics.
• Neuroscience Studies: Essential for in vitro and in vivo models investigating pain perception, anxiety, depression, and other central nervous system (CNS) functions.
• Biochemical Assay Development: Serves as a control inhibitor in enzymatic assays to measure FAAH activity and evaluate the potency of new chemical entities.
• Preclinical Animal Studies: Utilized to establish proof-of-concept for FAAH inhibition in disease models, informing potential clinical translation.

Basic Information

Product Name	Pf-04457845
CAS No.	1020315-31-4
Molecular Formula	C₂₀H₂₀F₃N₃O₂
Molecular Weight	391.39 g/mol
Synonyms	PF-04457845; PF 04457845; N-Pyridin-3-yl-4-[[3-[[5-(trifluoromethyl)pyridin-2-yl]oxy]phenyl]methyl]piperazine-1-carboxamide; 1-Piperazinecarboxamide, N-3-pyridinyl-4-[[3-[[5-(trifluoromethyl)-2-pyridinyl]oxy]phenyl]methyl]-; FAAH Inhibitor PF-04457845
EINECS	Contact for details

Quality Control

Our Pf-04457845 is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot is accompanied by comprehensive analytical data, including HPLC purity, NMR, and mass spectrometry for structural confirmation. Certificates of Analysis (COA) are available upon request to support your regulatory and documentation requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature, 15-25°C (59-77°F), in a dry environment. For long-term storage, consider storing desiccated at -20°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.