Description

4-(Difluoromethoxy)-2-Fluorobenzoic Acid is a high-value fluorinated aromatic building block, essential for the synthesis of advanced pharmaceutical intermediates and agrochemicals. Its unique difluoromethoxy and fluorine substituents impart critical metabolic stability and lipophilicity to target molecules, making it a sought-after reagent in modern drug discovery. This compound is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon in the development of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and fungicides, where the difluoromethoxy group enhances biological activity and environmental stability.
• Liquid Crystal Materials: Serves as a precursor for fluorinated liquid crystal compounds used in display technologies.
• Organic Electronic Materials: Employed in the synthesis of specialized monomers for polymers used in organic light-emitting diodes (OLEDs) and semiconductors.
• Chemical Research & Development: A versatile building block for exploring new chemical entities in medicinal and materials chemistry.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of client-specific complex molecules under cGMP conditions where required.

Basic Information

Product Name	4-(Difluoromethoxy)-2-Fluorobenzoic Acid
CAS No.	1017779-52-0
Molecular Formula	C8H5F3O3
Molecular Weight	206.12 g/mol
Synonyms	2-Fluoro-4-(difluoromethoxy)benzoic Acid; 4-(Difluoromethoxy)-2-fluorobenzoic Acid; Benzoic acid, 2-fluoro-4-(difluoromethoxy)-; 2-Fluoro-4-difluoromethoxybenzoic Acid; 1017779-52-0; 4-Difluoromethoxy-2-fluorobenzoic acid; 2-Fluoro-4-(difluoromethoxy)benzoic acid
EINECS	Contact for details

Quality Control

Our 4-(Difluoromethoxy)-2-Fluorobenzoic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and KF for moisture content, to ensure it meets the high standards required for research and commercial synthesis. A detailed Certificate of Analysis (COA) is provided with every shipment, and we support custom purity requirements for specific applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.