Description

(1R,2R)-2-(3,4-Difluorophenyl)Cyclopropane Carboxamide is a high-purity chiral cyclopropane derivative, a key advanced pharmaceutical intermediate (API) and building block in modern organic synthesis. Its precise stereochemistry and fluorinated aromatic system make it a critical component for developing novel, targeted therapeutics with enhanced metabolic stability and receptor binding affinity. This compound is essential for research and production in the pharmaceutical industry, particularly for medicinal chemists and process development teams working on central nervous system (CNS) agents, enzyme inhibitors, and other bioactive molecules.

Application

• Pharmaceutical Intermediate: A crucial chiral building block for the synthesis of novel active pharmaceutical ingredients (APIs), especially in CNS drug discovery.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization due to its constrained cyclopropane ring and fluorine substituents.
• Enzyme Inhibitor Development: Serves as a core scaffold for designing potent and selective inhibitors of various enzymes.
• Process Chemistry & Scale-up: Employed in route scouting and optimization for the commercial manufacturing of complex drug candidates.
• Asymmetric Synthesis: Utilized as a chiral synthon or auxiliary in stereoselective chemical transformations.
• Agrochemical Research: Potential intermediate for developing new crop protection agents with improved properties.

Basic Information

Product Name	(1R,2R)-2-(3,4-Difluorophenyl)Cyclopropane Carboxamide
CAS No.	1006376-62-0
Molecular Formula	C10H9F2NO
Molecular Weight	197.18 g/mol
Synonyms	(1R,2R)-2-(3,4-Difluorophenyl)cyclopropanecarboxamide; (1R,2R)-rel-2-(3,4-Difluorophenyl)cyclopropanecarboxamide; (1R-cis)-2-(3,4-Difluorophenyl)cyclopropanecarboxamide; 2-(3,4-Difluorophenyl)cyclopropanecarboxamide (1R,2R)-; Cyclopropanecarboxamide, 2-(3,4-difluorophenyl)-, (1R,2R)-; UNII-8J8V7Q6Y1Q; 8J8V7Q6Y1Q
EINECS	Contact for details

Quality Control

Our (1R,2R)-2-(3,4-Difluorophenyl)Cyclopropane Carboxamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical R&D and production. Certificates of Analysis (COA) detailing purity, chiral excess, and impurity profiles are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). The product is moisture-sensitive; keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.