Description

Ly 367385 is a potent and selective pharmacological agent, widely recognized in research for its specific antagonistic properties. This compound is a critical tool for investigating complex signaling pathways and their implications in various physiological and pathological states. It is primarily utilized by researchers and developers in the fields of neuroscience, pharmacology, and drug discovery for advanced in vitro and in vivo studies.

Application

• Neuroscientific Research: Used as a selective mGluR1 antagonist to study the role of metabotropic glutamate receptors in synaptic transmission, plasticity, and neurological disorders.
• Pharmacological Profiling: A key reference standard in high-throughput screening (HTS) and assay development for identifying and characterizing new therapeutic candidates.
• Drug Discovery & Development: Employed in preclinical studies to validate drug targets related to glutamate signaling, particularly for conditions like anxiety, pain, and neurodegenerative diseases.
• Academic & Institutional Research: Serves as an essential biochemical tool in university and institutional labs for fundamental research into cellular signaling mechanisms.
• Biotech R&D: Integral to the research pipelines of biotechnology companies focusing on central nervous system (CNS) targets and novel neuropharmaceuticals.

Basic Information

Product Name	Ly 367385
CAS No.	198419-91-9
Molecular Formula	C₁₈H₁₅NO₄
Molecular Weight	309.32 g/mol
Synonyms	(S)-(+)-α-Amino-4-carboxy-2-methylbenzeneacetic acid; (S)-4-Carboxyphenylglycine; (S)-4-CPG; LY-367385; (S)-α-Amino-4-carboxy-2-methylbenzenacetic acid; mGluR1 antagonist LY367385; Selective group I metabotropic glutamate receptor antagonist
EINECS	Contact for details

Quality Control

Every batch of Ly 367385 is manufactured and analyzed under strict quality management systems to ensure the highest standards of purity and consistency for research applications. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic methods, to ensure compliance with industry standards. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.