Description

2'-Trifluoromethylbiphenyl-4-Carboxylic Acid is a high-value, multi-functional aromatic carboxylic acid building block distinguished by its biphenyl core and trifluoromethyl substituent. This compound is essential for its role in modulating the physicochemical properties of target molecules, particularly in enhancing metabolic stability and lipophilicity. It is primarily sought after by research and development teams in the pharmaceutical and advanced materials sectors for the synthesis of novel active ingredients and functional polymers.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in oncology, CNS, and anti-inflammatory drug candidates.
• Agrochemical Synthesis: Used in the research and development of advanced herbicides and fungicides, where the trifluoromethyl group contributes to biological activity.
• Liquid Crystal & OLED Materials: Serves as a precursor for constructing rigid, conjugated structures used in electronic displays and organic light-emitting diodes.
• Polymer Modification: Incorporated as a monomer or cross-linking agent to create specialty polymers with enhanced thermal and chemical resistance.
• Chemical Research & Development: A versatile scaffold in medicinal chemistry for structure-activity relationship (SAR) studies and library synthesis.
• Coordination Chemistry: Acts as a ligand precursor for metal-organic frameworks (MOFs) and catalysts due to its carboxylic acid functionality.

Basic Information

Product Name	2'-Trifluoromethylbiphenyl-4-Carboxylic Acid
CAS No.	198205-79-7
Molecular Formula	C14H9F3O2
Molecular Weight	266.22 g/mol
Synonyms	[2-(Trifluoromethyl)phenyl]-4-benzoic Acid; 4'-Carboxy-2-(trifluoromethyl)biphenyl; 2-(Trifluoromethyl)biphenyl-4'-carboxylic Acid; 4-Biphenylcarboxylic Acid, 2'-trifluoromethyl-; 2'-Trifluoromethyl-4-biphenylcarboxylic Acid; 2'-Trifluoromethyl-[1,1'-biphenyl]-4-carboxylic Acid; Biphenyl-4-carboxylic acid, 2'-trifluoromethyl-
EINECS	Contact for details

Quality Control

Every batch of 2'-Trifluoromethylbiphenyl-4-Carboxylic Acid is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for sensitive applications like pharmaceutical R&D. A detailed Certificate of Analysis (COA) is supplied with each shipment, documenting key parameters including purity, identity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.